ea0086oc2.1 | Endocrine Cancer and Late Effects | SFEBES2022
Dissanayake Kumara
, Poland Conor
, Gierlinski Marek
, Davidson Lindsay
, Newey Paul
Introduction: Germline and somatic inactivating MEN1 variants are associated with a wide range of inherited and sporadic endocrine tumours. MEN1 encodes the tumour suppressor Menin, a ubiquitously expressed scaffold protein, implicated in multiple cellular processes including transcription, epigenetic regulation, and modulation of key signaling pathways. Despite intensive study, the mechanisms leading to endocrine tumorigenesis remain ill-defined, in part ref...